Immune Regulation
Basophils account for only around 1% of white blood cells but play a role in allergy defense and stimulate antibodies against pathogens and parasitic organisms (such as ticks and worms) that cause injury or infection.
Eosinophils are recruited to inflamed areas of the body to trap substances, kill infected cells, viruses, parasites, and bacteria, and help tame an allergic response. Testing can reveal issues in the digestive tract, specifically the esophagus, and includes both percentage and absolute levels.
Lymphocyte levels can reveal a number of conditions, including autoimmunity, bone marrow disorders, kidney disease, gastrointestinal disorders, and more. The role of lymphocytes in the body’s immune defense is so crucial that abnormal levels can weaken the body, leading to severe illness or impairing its ability to fight off infections. The test includes both percentage and absolute levels.
Like other white blood cells (WBCs), monocytes help the immune system destroy invaders and also facilitate healing and repair. Abnormal levels can indicate bacterial infections, virus or fungus, stress, chronic infections, or autoimmune disorders. The test includes both percentage and absolute levels.
Testing the quantity of neutrophils helps detect damage caused by inflammatory disorders (such as rheumatoid arthritis and gout), infections (both acute and chronic), certain cancers (such as myelocytic leukemia), and physical stressors (including eclampsia in pregnant women, injury, and burns). Neutrophils are key patrols and first responders in the immune system, attacking antigens they encounter. The test includes both percentage and absolute levels.
A healthy WBC baseline over time correlates with the body's ability to fight off diseases and other hazards. Prolonged abnormalities can negatively affect biological age by impairing healing and increasing the risk of illness.
hs-CRP is revelatory in one's overall health as it relates to the risk of inflammation-related diseases. Chronic inflammation is linked to every major disease: heart disease (even before symptoms occur), type 2 diabetes, cancer, high blood pressure, Alzheimer’s, depression, all autoimmune diseases, and severe allergic reactions like asthma.
C4a is part of the complement system—a network of proteins that enhances immune defense by fighting infections and clearing damaged cells—and plays a key role in regulating inflammation. Monitoring its activity can help assess its role in autoimmune diseases chronic infections and inflammatory conditions. *This add-on test is available for an additional cost and is not included in the $499 membership.
MMP-9 is an enzyme essential for tissue remodeling and repair playing a beneficial role in processes like wound healing and immune response. However when dysregulated it can contribute to excessive inflammation which is linked to cardiovascular disease autoimmune disorders and chronic inflammatory conditions. *This add-on test is available for an additional cost and is not included in the $499 membership.
Serum osmolality measures the concentration of dissolved particles in the blood such as electrolytes glucose and urea. This test helps assess hydration status kidney function and electrolyte balance offering valuable information on inflammatory conditions that affect fluid regulation and metabolic stability. *This add-on test is available for an additional cost and is not included in the $499 membership.
PAI-1 is a protein involved in maintaining the balance between blood clot formation and breakdown. Changes in its levels can impact cardiovascular health metabolic function and the regulation of clotting. Inflammatory conditions such as those affecting vascular health may also influence PAI-1 activity. *This add-on test is available for an additional cost and is not included in the $499 membership.
IgG Subclass 1 is the most abundant IgG subclass essential for protecting against bacterial and viral infections. Measuring its levels helps identify immune deficiencies tied to recurrent infections. *This add-on test is available for an additional cost and is not included in the $499 membership.
IgG Subclass 2 plays a key role in recognizing carbohydrate antigens on bacteria especially those with protective outer coatings (encapsulated pathogens). Abnormal levels may signal susceptibility to respiratory or sinus infections. *This add-on test is available for an additional cost and is not included in the $499 membership.
IgG Subclass 3 helps the immune system target proteins on harmful microbes and activate immune responses. Imbalances in this subclass are linked to challenges in fighting chronic infections. *This add-on test is available for an additional cost and is not included in the $499 membership.
IgG Subclass 4 helps regulate immune responses and is often associated with allergic reactions and autoimmune conditions. Levels outside the normal range can indicate immune system dysregulation. *This add-on test is available for an additional cost and is not included in the $499 membership.
Total IgG encompasses all IgG subclasses providing a broad overview of the immune system's capacity to defend against infections and maintain immunity. *This add-on test is available for an additional cost and is not included in the $499 membership.
IgM is the first antibody produced during an immune response offering rapid defense against infections. Variations in IgM levels can indicate how effectively the body mounts its initial immune response to infections or other foreign substances. *This add-on test is available for an additional cost and is not included in the $499 membership.
IgA is concentrated in mucosal surfaces like the respiratory and digestive tracts where it offers frontline defense against pathogens. Imbalances can point to vulnerabilities in mucosal immunity. *This add-on test is available for an additional cost and is not included in the $499 membership.
The average physical tests only 19 biomarkers.