The Antinuclear Antibodies (ANA) Pattern test analyzes the specific patterns of antibody staining on cells, providing detailed information that can aid in diagnosing and differentiating various autoimmune diseases. Different patterns, such as homogeneous, speckled, nucleolar, and centromere, are associated with specific autoimmune conditions, helping healthcare providers pinpoint the exact nature of the autoimmune response. This result is only processed if ANA screen is positive.

The Antinuclear Antibodies (ANA) Screen is a blood test that detects the presence of antibodies that mistakenly target and attack the nucleus of the body's cells. A positive ANA test suggests an autoimmune response, but further tests are usually required to determine the specific condition and guide appropriate treatment.

An ANA test assists in detecting autoimmune disorders. ANAs are autoantibodies produced by the immune system. While healthy antibodies protect the body from pathogens like viruses and bacteria, autoantibodies cause disease by mistakenly attacking healthy cells and tissues. This result is only processed if ANA screen is positive.

Rheumatoid factors (RFs) are antibodies produced by the immune system. The presence of RFs can indicate autoimmune disorders such as rheumatoid arthritis, rheumatoid vasculitis, or Sjögren’s syndrome. Asymptomatic individuals with elevated RF levels may have pre-autoimmunity.

These antibodies are specific markers for antiphospholipid syndrome and help identify clotting risks in autoimmune conditions. *This add-on test is available for an additional cost and is not included in the $499 membership.

Cardiolipin antibodies are linked to antiphospholipid syndrome a disorder that increases the risk of blood clots miscarriages and strokes. *This add-on test is available for an additional cost and is not included in the $499 membership.

Centromere B antibodies are strongly linked to limited scleroderma (CREST syndrome) and help assess the risk of pulmonary hypertension. *This add-on test is available for an additional cost and is not included in the $499 membership.

This antibody targets chromatin a structure of DNA and proteins. It is associated with systemic lupus erythematosus (SLE) and drug-induced lupus. *This add-on test is available for an additional cost and is not included in the $499 membership.

These proteins are part of the complement system which supports immune defense. Low levels are often associated with lupus and other autoimmune conditions. *This add-on test is available for an additional cost and is not included in the $499 membership.

CCP antibodies are highly specific for rheumatoid arthritis and can help diagnose the condition in its early stages. *This add-on test is available for an additional cost and is not included in the $499 membership.

This test detects antibodies targeting double-stranded DNA a hallmark of lupus. Elevated levels are highly specific for systemic lupus erythematosus (SLE) and can indicate disease activity. *This add-on test is available for an additional cost and is not included in the $499 membership.

ESR measures inflammation in the body and is often elevated in autoimmune conditions like rheumatoid arthritis lupus and vasculitis. *This add-on test is available for an additional cost and is not included in the $499 membership.

Jo-1 antibodies are markers for polymyositis and dermatomyositis autoimmune conditions that cause muscle inflammation and weakness. *This add-on test is available for an additional cost and is not included in the $499 membership.

MCV antibodies are markers for rheumatoid arthritis particularly in cases with joint inflammation or erosive joint-damaging disease. *This add-on test is available for an additional cost and is not included in the $499 membership.

Rheumatoid factor is commonly associated with rheumatoid arthritis but may also appear in other autoimmune diseases like Sjögren's syndrome. *This add-on test is available for an additional cost and is not included in the $499 membership.

RNP antibodies are strongly associated with mixed connective tissue disease (MCTD) and may also be present in lupus or scleroderma. *This add-on test is available for an additional cost and is not included in the $499 membership.

Scl-70 antibodies are associated with systemic sclerosis (scleroderma) particularly the diffuse form which affects skin and internal organs. *This add-on test is available for an additional cost and is not included in the $499 membership.

These antibodies are markers for Sjögren's syndrome and may also be present in lupus. They help diagnose and differentiate between autoimmune conditions. *This add-on test is available for an additional cost and is not included in the $499 membership.

Sm antibodies are highly specific markers for systemic lupus erythematosus (SLE) and are rarely found in other conditions making them key in confirming a lupus diagnosis. *This add-on test is available for an additional cost and is not included in the $499 membership.

TPO antibodies target thyroid enzymes and are associated with autoimmune thyroid conditions such as Hashimoto's thyroiditis and Graves' disease.

Deamidated gliadin is a modified form of gliadin, a protein found in gluten. In the digestive process, gliadin undergoes deamidation, a chemical change where certain amino acids are altered, making it more likely to trigger an immune response in people with celiac disease or gluten sensitivity. The deamidated gliadin antibody test (IgA, IgG) helps detect this immune reaction, making it a useful marker for diagnosing celiac disease and monitoring gluten-related disorders. *This add-on test is available for an additional cost and is not included in the $499 membership.

Tissue transglutaminase (tTG) is an enzyme that modifies proteins and plays a role in tissue repair. In celiac disease, the immune system produces antibodies against tTG when gluten is consumed, leading to inflammation and intestinal damage. The tissue transglutaminase antibody test (IgA, IgG) detects this immune response and is considered the most reliable screening test for celiac disease. *This add-on test is available for an additional cost and is not included in the $499 membership.

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Detects antibodies to Sm and RNP which are associated with mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). *This add-on test is available for an additional cost and is not included in the $499 membership.